I thought it was obvious that, had Weaver not turned them down the first time they asked, Dana would have had the role in the game that evolved into Illyssa Selwyn. The fact sheet Atari put out even mentioned her playing violin and cello–a bit of a vestigal trait from the orignal plan, I think.
Considering how heavily they leaned on the first movie, and worked to retcon in a connection between Vigo's plot and Shandor's, having Dana be the descendant of Shandor and central Macguffin of the plot would have gone a ways toward “justifying” her imporance in both movies.
But that didn't happen, and it seems to be Dana's place in the mythos to either be at the center of everything's attention, or ignored so completely nobody even mentions her.